The GFAP Antibody: Biotin from MyBioSource.com is a Mouse Monoclonal antibody to GFAP, and Glial Fibrillary Acidic Protein. This antibody recognizes Human, Mouse, and Rat antigen. The GFAP Antibody: Biotin has been validated for the following applications: Immunocytochemistry, Immunohistochemistry, and Western Blot.
Description
Background Info: Detects a 50kDa protein in WB. Cross-reacts with GFAP-R416W and other GFAP mutant proteins.
Scientific Background: The 50 kDa type III intermediate filament protein glial fibrillary acidic protein (GFAP) is a major structural component of astrocytes. GFAP associates with the calcium binding protein annexin II-p2 and S-100. Association with these proteins together with phosphorylation regulates GFAP polymerization. Astroycytes respond to brain injury by proliferatin (astrogliosis), and one of the first events to occur during astrocyte proiliferation is increased GFAP expression. Interestingly, antibodies to GFAP have been detected in individuals with dementia